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The structure in the unliganded double mutant HIV-1 RT confirmed that Lys103Asn mutation facilitates coordination of the sodium ion with Lys101 O, Asn103 N and O(delta1), Tyr188 O(eta), and two h2o molecules. The formation of the binding pocket needs the removing in the sodium ion. Even though the RT alone as well as RT/HBY 097 intricate were cryst